Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
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منابع مشابه
Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
Although statins are widely prescribed medications, there remains considerable variability in therapeutic response. Genetics can explain only part of this variability. Metabolomics is a global biochemical approach that provides powerful tools for mapping pathways implicated in disease and in response to treatment. Metabolomics captures net interactions between genome, microbiome and the environ...
متن کاملMicrobiome, metabolites and host immunity.
In the intestine, the microbial genomes and repertoire of biochemical reactions outnumber those of the host and significantly contribute to many aspects of the host's health, including metabolism, immunity, development and behavior, while microbial community imbalance is associated with disease. The crosstalk between the host and its microbiome occurs in part through the secretion of metabolite...
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Immunotherapy has become one of the most profound advances in the treatment of solid tumors. Unlike the prior targeted therapies such as kinase inhibitors, there are no clear mutations or definitive biomarkers of which patients are likely to respond. It is well documented that many patients with PDL1 negative tumors can still have profound responses to PD1 inhibitors. As such there is a critica...
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Several studies have linked bacterial dysbiosis with elevated risk of colorectal adenomas and cancer. However, the functional implications of gut dysbiosis remain unclear. Gut bacteria contribute to nutrient metabolism and produce small molecules termed the "metabolome", which may contribute to the development of neoplasia in the large bowel. We assessed the metabolome in normal rectal mucosal ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0025482